Animal bones and skulls feature frequently in Georgia O'Keeffe's work, including some of her most famous paintings
Typically she would arrange these items into the precise look that she was after, similar to how Paul Cezanne would have arranged his still life flowers, or Ansel Adams the leaves in some of his black and white photographs. The plentiful objects scattered around New Mexico offered O'Keeffe an infinite supply of items to use and experiment with for her work.
Others would not have had the same passion for bones as this artist, who seemed to connect with them and see something in them that others could not. In being characteristic of her new home in New Mexico, where she was particularly happy to be, their use may have reflected her new found comfort. She would go on to include this region in landscape paintings too.