In Cow's Skull with Calico Roses, artist O'Keeffe decorated the skull with several plastic flowers. She took the idea from graves in New Mexico. The painting was first exhibited between 1931 and 1932 in a local gallery.

Artist Georgia was famous for collecting animal bones in her local environment as tools for her work but there is a little more interest to be found in this particular painting.

Cow's Skull with Calico Roses in Detail Georgia O'Keeffe